A clinical case of the use of a combination of cimicoxib and cyclophosphamide in metronomic mode in neoadjuvant therapy of complex breast carcinoma of a dog

The results of the use a combination cimicoxib and cyclophosphamide, in metronomic mode, neoadjuvant therapy complex breast carcinoma dogs are presented. This treatment regimen allowed to achieve stabilization process, volume tumor decreased by 60.77% indicators first day. regression was 39.23%. According hematological blood examination, 90th day therapy, number leukocytes 75.96%, lymphocytes 79.67% granulocytes 75.64%, reference values. red cells level hemoglobin increased 49.57% 53.98%, respectively. There an increase amount hematocrit 52.35% compared values before therapy. Biochemical parameters serum end drug were within no signs general toxicity, according WHO scale, requiring corrective dose reduction or withdrawal drugs.